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Active ProjectsVery high-resolution optical microscopeAn optical microscope for use in fluorescence or bright field modes with resolution of 50 nm (currently) and possibly 10 nm (future) is being developed. This microscope is intended for use in studying biological systems which, so far, have been hampered by a combination of the lack of resolution and/or the inability to image living cells. Examples include:
The fundamental invention upon which this microscope is based, surface plasmon enhanced microscopy (SPEM) can also be applied to high density optical data storage delivering areal density of 2 Terabits per square inch, lithography for semiconductor fabrication with line widths projected to be as narrow as 10 nm, as a highly multiplexed biosensor for detecting multiple analytes, and a device to study protein conformational dynamics at the single molecule level. (read more) Benchtop Bioreactor for growth of Anterior Cruciate Ligament tissueA benchtop bioreactor for growing ACL tissue has been designed and built. This bioreactor applies mechanical forces to induce mesenchymal progenitor cells to differentiate into ACL tissue. Current work is focused on adding force monitoring and orientation control to the bioreactor while making the design applicable to more tissues (muscle, bone, tendon, ligament, cartilage, and neurons). High-throughput device for protein purificationA device is being designed to allow “walk-away” automation
for protein purification by affinity methods (Ni-His, immunoprecipitation)
in a 96 well format. This device can also be used for performing high-throughput
experiments on Xenopus oocytes, embryos, and other small objects. Colony picker selection and implementation, and design of custom plastic wareA colony picker has been selected and is being implemented in the Harvard Institute of Proteomics (HIP) to pick colonies in a 96 well format. A custom plastic component has been designed to enable this operation and tooling is currently being prepared. (read more) TEC is currently collaborating on a design for a crystal-holding device for very small protein crystals. All of these devices are available for licensing. For more information contact:
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